Sero-epidemiology of Marburg virus amongst respondents in Sobi Area, Ilorin, Kwara State, Nigeria
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Abstract
Marburg virus disease is a hemorrhagic fever of public health importance. There is sparse information on its prevalence in Nigeria. This study was aimed at determining the serological epidemiology and molecular confirmation of MV amongst inhabitants of Sobi in Ilorin, Nigeria in order to forestall a potential outbreak of MVD. Serological evaluation of collected blood samples from consenting participants was carried out using MELSIN ELISA kit for antibody detection. Structured questionnaire was used to collect risk factor data. This study revealed the serological presence of Marburg virus IgG (26.5%) and IgM (19.0%) in this locality(P<0.05). MV IgG and IgM prevalence by evaluated risk factors were 12 (23.5%) and 6 (16.7%), 11 (21.6%) and 9 (25.0%), and 27 (50.9%) and 13 (34.2%) for presence of bats in vicinity, respondent’s visitation to park/zoo and presence of trees in residential area respectively at varying statistical correlations. Consumption of sick animals, contact with dead animals and involvement in preparation of dead body for burial showed an IgG/IgM positivity of 4 (7.7%)/2 (5.4%), 3 (5.8%)/4 (10.8%) and 11 (21.2%)/4 (10.8%) respectively. Higher frequency of contact or closer proximity to known risk factors showed higher prevalence and bats within vicinity revealed to be more amongst respondent with tree in residential area than those closer to Sobi hill. Reduction of bat to human contact and hygienic practices in occupation/research involving animals should be encouraged.
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References
Araoye, M. O. (2004). Sample size determination in research methodology with Statistics for health and social Sciences. Nathadex Publishers, Ilorin. 115-121
Bannister, B. (2010). Viral haemorrhagic fevers imported into non-endemic countries: risk assessment and management. British Medical Bulletin; 95:193-95
Barrette, R.W., Metwally, S.A., Rowland, J.M., Xu, L., Zaki, S.R., Nichol, S.T., Rollin, P.E., Towner, J.S., Shieh, W.J., Batten, B., Sealy, T.K., Carrillo, C., Moran, K.E., Bracht, A.J., Mayr, G.A., Sirios-Cruz, M., Catbagan, D.P., Lautner, E.A., Ksiazek, T.G., White, W.R. and McIntosh, M.T. (2009). Discovery of swine as a host for the Reston ebolavirus. Science; 325:204–206.
Bausch, D.G., Nichol, S.T., Muyembe-Tamfum, J.J., Borchert, M. and Rollin, P.E. (2006). Marburg hemorrhagic fever associated with multiple genetic lineages of virus. N Engl J Med; 355:909-9193
Bermejo, M., Rodríguez-Teijeiro, J.D., Illera, G., Barroso, A., Vilà, C. and Walsh, P.D. (2006). Ebola outbreak killed 5000 gorillas. Science; 8; 314:1564.
Centers for Disease Control, Prevention (2009). Imported case of Marburg hemorrhagic fever—Colorado. MMWR Morb Mortal Wkly Rep. ;58(49):1377–81. PubMed PMID: 20019654.
Centers for Disease Control, Prevention (2014). Marburg hemorrhagic fever. https://www.cdc.gov/vhf/marburg/transmission/index.html
Centre for Disease Control and Prevention (CDC) (2008). Outbreak of Ebola hemorrhagic fever Uganda August 2000- January 2001. MMWR: Morb Mortal Wkly Rep 50:73-7
Ftika, L. and Maltezou, H.C. (2013). Viral hemorrhagic fevers in healthcare settings. Journals of hospital infection. 83 (3): 185-92. dio: 10.1016/ J.Jhin. 2012.10.013. Pmid: 23333147
Heinz, F. and Hans-Dieter, K. Chapter 72; Filoviruses. Medical Microbiology. 4th edition. Baron S, editor. Galveston (TX): 1996; University of Texas Medical Branch at Galveston.
Knust, B., Schafer, I.J., Wamala, J., Nyakarahuka, L., Okot, C. and Shoemaker, T. (2012). Multidistrict Outbreak of Marburg Virus Disease-Uganda. J Infect Dis. 2: S119–28.
Kortepeter, M.G., Bausch, D.G. and Bray, M. (2011). Basic clinical and laboratory features of filoviral hemorrhagic fever. J infect Dis. 204:S810-6
Lloyd, G. Oxford Textbook of Zoonoses 2011: Biology, clinical practice and public health control (2nd ed.) 2:4-10
Macneil, A. and Rollin, P.E. (2012). Ebola and Marburg hemorrhagic fever: Neglected tropical disease? Plos Negl Trop Dis. 6: e1546
Masfique, M., Allison, G., Heinz, F. and Hideki, E. (2011). Clinical Aspects of Marburg Hemorrhagic Fever. Future Virology. 6(9):1091-1106.
Mehedi, M., Groseth, A. and Feldmann, H. (2011). Clinical aspects of Marburg hemorrhagic fever. Future Virology. 6(9):1091-1063
Mohan, N., Stig M. J., Sarah, L. K., Teddy, K., Ana, I. K., Spencer, W. S., Julius, J.L., Leslie, L., John, M.D. and Robert, G.U. (2016). Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses. Clinical Immunology. DOI: 10.1128/CVI.00107-163
Nyakarahuka, L., Kankya, C., Krontveit, R., Mayer, B., Mwiine, F.N., Lutwama, J. and Skjerve, E. (2016). How severe and prevalent are Ebola and Marburg viruses? A systematic review and meta-analysis of the case fatality rates and seroprevalence. BMC Infect Dis. 25; 16(1):708.
Pigott, D.M., Golding, N., Mylne, A., Huang, Z., Henry, A.J., Weiss, D.J., Brady, O.J., Kraemer, M.U., Smith, D.L., Moyes, C.L., Bhatt, S., Gething, P.W., Horby, P.W., Bogoch, I.I., Brownstein, J.S., Mekaru, S.R., Tatem, A.J., Khan, K. and Hay, S.I. (2014). Mapping the zoonotic niche of Ebola virus disease in Africa; 8;3:e04395.
Slenczka, W. and Klenk, H.D. (2007). Forty years of Marburg virus. Journal of. Infectious. Disease. 196 (Suppl. 2), S131–S135.
Stefan, P. (2019). 15 years field research North American endangered species. Updated Mar 21, https://www.quora.com/What-environments-do-fruit-bats-live-in
Swanepoel, R., Smith, S.B. and Rollin P.E. (2007). Studies of reservoir host for Marburg virus. Emerging Infecting disease. 13(12):1847-51
Towner, J. (2006). Marburg virus genomics and association with a large hemorrhagic fever outbreak in Angola. J virol. 6;497-516
Towner, J., Amman, B. and Sealy, T. (2009). Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLOS Pathog. 5: e000536.
World Health Organization (2017). Marburg virus disease Fact sheet available at http://www.who.int/mediacentre/factsheets/fs_marburg/en
World health Organization (2014). Field Situation: how to conduct safe and dignified burial of the patient who has died of a suspected or confirmed Ebola virus disease.
World health Organization (2017). Marburg Hemorrhagic fever in Uganda. Wkly Epidermiol Rec. 85:255-6
Zeller, H. and Georges-Courbet, M.C. (2006). Les Fievres hemorragiques virales Antibiotiques 8(4):125-220