Evaluation of the leaf Extract of Blighia Sapida K.D. Koenig for sedative, Anticonvulsant and Antidepressant-like properties in mice
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Abstract
Background/Aim: Blighia sapida (BS) is a widely used medicinal plant in West Africa. Its leaf has been reported in folkloric medicine to be used in the management of migraines, epilepsy, pains, and several other diseases. However, there is limited knowledge about the scientific basis for its folkloric use in the management of epilepsy and other central nervous system (CNS)-related disorders. The study was aimed at evaluating the sedative, anticonvulsant, and antidepressant-like properties of the aqueous leaf extract of BS in mice. Methods: The extraction process was by cold maceration for three days. Twenty-five mice (n = 5) of both sexes were used for each of the evaluations (diazepam induced sleep time, anticonvulsant and antidepressant tests) at oral doses of 125, 250, and 500 mg/kg p.o. of BS. Results: Doses of BS shortened diazepam-induced sleep time in mice, and did not protect the mice against pentylenetetrazole (PTZ) and maximum electroshock (MES)-induced convulsion. BS increased duration of immobility in both the tail suspension test (TST) and forced swimming test (FST) in mice. Conclusion: These finding show that BS lacks sedative-hypnotic effect and has no anticonvulsant and antidepressant activities. The results from this study do not justify its use in the treatment of epilepsy and some CNS-related disorders such as depression.
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